This disorder is one of the most common metabolic disorders during pregnancy.
If this disorder of blood glucose regulation occurs for the first time during pregnancy, it is called gestational diabetes. Pregnancy changes affect glucose metabolism and insulin sensitivity. Iranian Registry of Clinical Trials (IRCT): IRCT20120718010324N59. Vitamin D could improve the musculoskeletal pain in pregnant women but couldn’t decrease FBG, FBI, HOMA-IR, depression symptoms score, incidence of GDM and abortion. ResultsĪfter the intervention, there was no statistically significant difference between the two groups in terms of FBG (P = 0.850), FBI (P = 0.353), HOMA-IR (P = 0.632), mean score of depressive symptoms (P = 0.505), frequency of gestational diabetes (P = 0.187) and frequency of abortion (P = 1.000) and there was only a difference in terms of serum vitamin D level (P = 0.016) and musculoskeletal pain including knee pain (P = 0.025), ankle pain (P < 0.001) and leg pain (P < 0.001). Independent t-test, Mann-Whitney U and ANCOVA tests were used to analyze the data.
The vitamin D group received 4,000 units of vitamin D tablets daily and the control group received placebo tablets for 18 weeks. In this triple-blind randomized controlled trial, 88 pregnant women at 8–10 weeks of pregnancy who had the vitamin D of less than 30 ng/ml were randomly assigned to the vitamin D group (n = 44) and control group (n = 44) using block randomization. Therefore, the purpose of the present study was to determine the effect of vitamin D supplementation on fasting blood glucose (FBG) levels, fasting blood insulin (FBI) levels and insulin resistance index (HOMA-IR) (primary outcomes) and symptoms of depression, musculoskeletal pain, frequency of gestational diabetes and the frequency of abortion (secondary outcomes). Some studies have reported the effect of vitamin D deficiency on the incidence of this disorder. Gestational diabetes is one of the most common metabolic disorders during pregnancy.
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